Research Activity 2004/05

A randomised study of the effect of treatment with Combivir (Zidovudine and Lamivudine) and Kaletra (Lopinavir), alone and in combination, on the development of abnormalities in lipid and glucose metabolism in HIV negative healthy subjects.

HIV, Cardiology and Endocrinology Units, SVH.

Carr A,
Cooper D, Mallon P,  Chisholm D,
Kelleher A,
Samaras K,
Williams K,
Feneley M.

Investigating HIV medication and its effect on sugar and fat metabolism in healthy subjects.

A Phase III multi-centre, double-blind, randomised, parallel-group evaluation of the fixed combination Torcetraphib / Atorvastatin administered daily, compared with Atorvastatin alone on the occurrence of major cardiovascular events in subjects with coronary heart disease or risk equivalent.

MPU Cardiology, SVH.

Simons L.

Comparing two cholesterol lowering medications in people with heart disease.

Hepatitis C virus diversity in patients co-infected with human immunodeficiency virus (HIV).

National Centre for HIV Epidemiology and  Clinical Research.

Dore G,  Cunningham P, White P,
Kaldor J, Micallef J.

Investigating hepatitis C in HIV positive patients.

A 48 week, randomised study to describe the pharmacokinetic profile and durability of Atazanavir-Saquinavir-Ritonavir once daily, and describe the pharmacokinetic profile of Saquinavir-Ritonavir using Saquinavir 500mg formulation.

HIV Medicine, SVH.

Cooper D,
Winston A, 
Emery S,
Mallonn P,
Williams K.

Looking at the pharmacokinetic effects of once daily HIV medication.

Management of delirium by palliative care and oncology specialists: descriptive study of current practice.

Sacred Heart Hospice.

Agar M,
Draper B.

Descriptive study of current practice of delirium management by doctors.

A multi-centre, Phase II study to investigate the safety and activity of SDX-105 (Bendamustine) in combination with Rituximab in patients with relapsed indolent or mantle cell non-Hodgkin's lymphoma.

Haematology, SVH.

Dodds A,
Ma D,
Moore J,
Milliken S,
Fay K.

Testing a new drug for non-Hodgkin's lymphoma.

A Phase II trial in patients with previously untreated acute promyelocytic leukaemia, to evaluate the effects of: 1. Adding arsenic trioxide to all trans retinoic acid and Idarubicin for remission induction, and 2. Adding arsenic trioxide to all trans retinoic acid as consolidation.

Haematology, SVH.

Moore J,
Dodds A,
Ma D,
Fay K,
Milliken S.

Investigating treatments for acute promyelocytic leukaemia.

A randomised trial of Idarubicin escalation in consolidation therapy following intensive induction chemotherapy incorporating high dose cytarabine in patients with untreated adult acute myeloid leukaemia.

Haematology, SVH.

Moore J,
Dodds A,
Ma D,
Fay K,
Milliken S.

Escalating drug doses of chemotherapy for leukaemia patients.

Interactions between herbal medicines and the anticoagulant warfarin.

Clinical Trials Centre.

McLachlan A,  Williams K,
Day R,
Liauw W,
Jiang JX, 
Abdul Mohi Iqbal M.

Interactions between herbal medicines and the anticoagulant warfarin.

A multi-centre, multi-national, phase III, open-label extension trial to assess the safety of long term treatment of Rotigotine patch in subjects with advanced stage, idiopathic Parkinson’s Disease who are not well controlled on Levadopa.

Neurology, SVH.

Brew B,
O’Sulllivan D, 
Liauw W.

Testing a drug for Parkinson’s disease which is delivered using a patch on the skin.

Epigenetic variation in early human development.

Garvan Institute.

Clark S,
Dwye P, 
Roach V.

A Phase Ib, observer-blind, randomised, placebo-controlled, dose escalation study to determine the safety, tolerability and immunogenicity of human papilloma virus (HPV) immunotherapeutic in HIV-positive participants with oncogenic HPV infection of the anus.

HIV Medicine, SVH.

Hillman R, Cooper D,
Carr A.

Observational study of HIV-positive participants with oncogenic HPV infection of the anus.

Open, randomised, controlled, multi-centre, Phase III study comparing 5FU/FA plus Irinotecan plus Cetuximab, versus 5FU/FA plus Irinotecan as first line treatment for epidermal growth factor receptor expressing metastatic colorectal cancer. (CRYSTAL – Cetuximab combined with Irinotecan in First Line Therapy for Metastatic Colorectal Cancer).

Medical Oncology, SVH.

Ward R, Segelov E, Dalley D, Grygiel J.

Comparing two forms of chemotherapy for patients with metastatic colorectal cancer.

A multi-centre, open-label, single arm safety study to investigate the effects of chronic TRACLEAR treatment on testicular function in male patients with pulmonary hypertension.

Cardiopulmonary Transplant, SVH.

Keogh A, Kotylar E,  Macdonald P,  Hayward C,  Schnider L,
Swaraj K.

Testing the effects of drug treatment on testicular function in male patients with pulmonary hypertension.

A multi-centre, multi-national, randomised, double-blind, placebo-controlled, proof on concept trial to assess the effects of a subject-optimised dose of UK-369,003 modified release, on exercise capacity in subjects with pulmonary hypertension associated with chronic obstructive pulmonary disease.

Thoracic Transplant, SVH.

Glanville A,
Yates D,
Malouf M,
Plit M,  Aboyoun C.

Testing the effects of a new drug for pulmonary hypertension associated with chronic obstructive pulmonary disease.

Generation of intervertebral disc cells from human adult bone marrow mesenchymal stem cells.

Haematology, SVH.

Tao H,
Ma D,
Hsu J.

Multicultural promotion of the community Palliative Care Service at the Sacred Heart Hospice. 

Sacred Heart Hospice.

McGuire J.

Promoting the Community Palliative Care Service at Sacred Heart to the culturally and linguistically diverse community.

A randomised, Phase III trial of ALIMTA and Cisplatin versus GEMZAR and Cisplatin, in patients with locally advanced or metastatic non-small cell lung cancer.

Medical Oncology, SVH.

Grygiel J,
Dalley D,
Ward R,
Sevlegov E.

Comparing two chemotherapy regimes for the treatment of advanced or metastatic non-small cell lung cancer.

A randomised, Phase II study evaluating a weekly schedule of Docetaxel with Cisplatin and 5FU (wTCF) or with Capecitabine (wTX) in advanced oesophageal-gastric cancer.

Medical Oncology, SVH.

Sevlegov E,
Dalley D,
Ward R,
Grygiel J.

Comparing two chemotherapy regimes for the treatment of advanced oesophageal-gastric cancer.

A multi-centre, randomised, double-blind, comparative trial of novel CCR5 antagonist, UK-427,857, in combination with Zidovudine / Lamivudine (Combivir) versus Efavirenz in combination with Zidovudine / Lamivudine (Combivir) for the treatment of antiretroviral-naïve HIV-1 infected subjects.

HIV Medicine, SVH.

Cooper D,
Carr A,
Marriott D,
Mallon P,
Winston A, 
Pett S,
Brew B, 
Hamlyn E.

Trialling a new drug for the treatment of HIV.

A multi-centre, randomised, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427,857, in combination with optimised background therapy versus optimised background therapy alone for the treatment of antiretroviral - experienced, non CCR5-tropic HIV-1 infected subject.

HIV Medicine, SVH.

Cooper D,
Carr A,
Marriott D,
Mallon P,
Winston A, 
Pett S,
Brew B, 
Hamlyn E.

Trialling a new drug for the treatment of HIV.

A multi-centre, randomised, double-blind, placebo-controlled trial of a novel CCR5 antagonist, UK-427,857, in combination with optimised background therapy versus optimised background therapy alone for the treatment of antiretroviral-experienced HIV-1 infected subjects.

HIV Medicine, SVH.

Cooper D,
Carr A, 
Marriott  D,
Mallon P,
Winston A, 
Pett S, Brew B,  Hamlyn E.

Trialling a new drug for the treatment of HIV.

A randomised, controlled study of DOXIL / CAELYX (Doxorubicin HCL liposome injection) and VELCADE (Bortezomib) or VELCADE monotherapy for the treatment of relapsed multiple myeloma.

Haematology, SVH.

Ma D,
Dodds A,
Moore J,
Milliken S,
Fay K.

Comparing two chemotherapy regimes for the treatment of relapsed multiple myeloma.

A Phase III, randomised, open-label, multi-centre study of Irinotecan and Cetuximab versus Irinotecan as second-line treatment in patients with metastatic, EGFR-positive colorectal carcinoma (EPIC study).

Medical Oncology, SVH.

Sevlegov E,
Ward R,
Dalley D,
Grygiel J.

Comparing two chemotherapy regimes for the treatment of colorectal cancer.

Potential of human adult bone marrow stem cells for the treatment of Parkinson’s Disease and multiple sclerosis.

Haematology, SVH.

Ma D,
Tao H,
Khoo M.

Investigating the potential of human adult bone marrow stem cells to treat Parkinson’s Disease and Multiple Sclerosis.

Effects of fasting and re-feeding on the regulation of glucose and fat metabolism: studies in relatives of type 2 diabetic patients and control subjects. 

Diabetes Centre, SVH.

Campbell L,  Chisholm D, Gregersen S,  Hermansen K.

Effects of fasting and re-feeding on the regulation of glucose and fat metabolism in people with diabetes.

Preventing falls in hospitals: a randomised, controlled trial of patient and staff training.

St Vincent’s Hospital, SVH.

Cumming R, Brennan N, 
Broe TA,
Lord S.

Assessing the effectiveness of falls training for patients and staff in preventing falls.

A retrospective study of the clinical experience of Cancidas (caspofungin acetate) use in the treatment of invasive fungal infections in adults.

Microbiology, SVH.

Pett S,
Marriott D.

A retrospective study of the clinical experience of a drug used in the treatment of invasive fungal infections.

The development and evaluation of written medicines information for patients with type 2 diabetes.

Pharmacy, SVH.

Krass I,
Armour C,
Lee D.

To improve, where possible, the information provided to patients.

The role of the insulin-like growth factor family in pulmonary disease: Bleomycin and pulmonary toxicity.

Thoracic Medicine, SVH.

Stone E, Martin J, Baxter R, Yates D.

Investigating the role of the insulin-like growth factor family in pulmonary disease.

Phase III, multi-centre, double-blind, randomised, parallel group study of the efficacy, safety and tolerability of fixed combination Torcetrapid (cp529,414) / Atorvastatin administered orally, once daily for six months, compared with maximally tolerated Atorvastatin therapy alone, in subjects with heterozygous familial hypercholesterolemia. 

Medical Professorial Unit, SVH.

Simon L.

Comparing twp drugs used to treat high cholesterol.

Effects of insulin in lymphocyte and neutrophil function.

Garvan Institute.

Chisholm D,
Viardot A.

Investigating the effects of insulin in white blood cells.

A randomised, placebo-controlled, multi-centre, Phase I/II study of escalating single intravenous doses of rhuMAB 2H7 (Ro 496-4913, PRO70769) in patients with moderate to severe rheumatoid arthritis, receiving stable doses of methotrexate but with unsatisfactory clinical response.

Clinical Trials Centre, SVH.

Day R,
Liauw W,
Williams K.

Testing the effect of a drug developed to treat rheumatoid arthritis.

An initial human study with placebo and positive control, to determine the safety and tolerability of two pharmaceutical forms of oral parathyroid hormone in post-menopausal female volunteers.

Clinical Trials Centre, SVH.

Sambrook P,
Day R,
Liauw W,
Williams K.

Testing the safety and tolerability of pharmaceutical forms of oral parathyroid hormone.

A comparison of Prasugrel (CS-747) and Clopidogrel in acute coronary syndrome subjects who are to undergo percutaneous coronary intervention/TIMI-38.

Cardiac Catheterisation Laboratory, SVH.

Wilson S,
Muller D, Roy P, Barron D, Liauw D,
Preisz P.

Comparing two drugs that stop the formation of blood clots in patients that have just had a stent placed in their coronary artery.

Early glycoprotein IIb/IIIa inhibition in non-ST segment elevation acute coronary syndrome:  a randomised, placebo-controlled trial evaluating the clinical benefits of early front loaded eptifibatide in the treatment of patients with non-ST segment evaluation Acute Coronary Syndrome (EARLY ACS).

Cardiac Catheterisation Laboratory, SVH.

Wilson S,
Muller D,
Roy P,
Barron D,
Liauw D,
Preisz P.

Evaluating the clinical benefits of early drug treatment in patients with acute coronary syndrome.

Motor Accident Acute Rehabilitation Response Strategy (MAARRS).

Rehabilitation Medicine, SVH.

Faux S,  Bowman M, Wilson S, Williams K, Liauw W.

Assessing the Motor Accident Acute Rehabilitation Response Strategy.

High dose Cytarabine and Fludarabine without Anthracycline for patients with core binding factor acute myeloid leukaemia.

Haematology, SVH.

Ma D, Dodds A, Moore J, Milliken S,
Fay K.

Trial testing chemotherapy for leukaemia.

A multi-centre, randomised, double-blind, placebo-controlled clinical trial examining the efficacy and safety of low dose Aspirin after initial oral anticoagulation to prevent recurrent venous thromboembolism.

Haematology, SVH.

Joseph J,
McGrath M,
Ma D,
Fay K.

Testing the safety of low dose Aspirin after initial oral blood thinners, to prevent recurrent clots.

Investigation of postnasal drip.

St Vincent’s Clinic.

Rimmer J,
Gallagher R,
Harvey R.

Investigation of postnasal drip to improve patient care.

A prospective, randomised, double-blind clinical trial on the efficacy of continuous local anaesthetic infusions via Stryker® pain relief pump, in reducing narcotic requirements after unilateral total knee replacement.

St Vincent’s Clinic.

Neal M,
O’Keefe C,
Kane C.

Testing a continuous pain relief infusions, via a device, in reducing narcotic requirements after total knee replacement.

Pathogenesis of persistent human virus infections of global significance.

Neuroscience and Neurology, SVH.

Brew B,  Cunningham A, Crowe S, Lewin S, Slobedman B, Wesselingh S.

Looking at the origin of persistent human virus infections of global significance.

Development and evaluation of the 'double balloon' technique of enteroscopy at St Vincent’s Hospital.

Medicine, SVH.

Frommer D.

Development and evaluation of a new surgical technique.

Chart review of skin diseases of HIV positive patients.

Skin and Cancer Foundation.

Whitfeld M, Bao Y.

Investigating skin diseases in patients with HIV.

First line Bevacizumab and chemotherapy in metastatic cancer of the colon or rectum: an expanded access program.

Medical Oncology, SVH.

Ward R, Segelov E, Dalley D, Grygiel J.

An expanded access program for chemotherapy in patients with cancer of the colon or rectum.

Evaluation of two doses of SR31747A9 (75mg and 125mg) in non-metastatic androgen-independent prostate cancer. Randomised, double-blind, placebo-controlled, Phase II study.

Medical Oncology, SVH.

Grygiel J,
Ward R,
Segelov E,
Dalley D.

Comparing two doses of the same drug for the treatment of prostate cancer.

How androgens exert their anabolic effects: interaction of testosterone and growth hormone at the hepatic level.

Garvan Institute.

Ho K, Meinhardt U, Handelsman D, Seibel M.

Investigating the interaction of testosterone and growth hormone in the liver.

Understanding the relationship between insulin resistance and chronic hepatitis C infection.

Diabetes Centre, SVH.

Chisholm D, Dore G, George J, Milner KL.

Understanding the relationship between insulin resistance and chronic hepatitis C infection.

Occult Paracetamol Toxicity Project.

Chemical Pathology, SVH.

Jones G,  Preisz P, Brien J.

Multi-centre, double-blind, randomised, dose-ranging study to compare the safety and activity of L-000900612 plus Tenofovir and Lamivudine (3TC) versus Efavirenz plus Tenofovir and Lamivudine (3TC) in antiretroviral naïve, HIV infected patients.

HIV Medicine, SVH.

Cooper D, Carr A, Pett S, Brew B, Marriott D,
Mallon P,
Winston A, Witherington C.

Comparing two drug therapies for HIV.

A Phase III, randomised, controlled, open-label, multi-centre, three-arm study to compare the efficacy and safety of a dual-boosted HIV-1 protease inhibitor (PI) regimen of Fosamprenavir (FPV) / Lopinavir (LPV) / Ritonavir (RTV) 1400mg/533mg/133mg twice daily(BID) and an increased dosage regimen of FPV/RTV 1400mg/100mgBID versus the standard dosage regimen of FPV/RTV 700mg/100mg BID for 24 weeks in multiple-PI experienced, HIV-infected adults experiencing virological failure.

HIV Medicine, SVH.

Cooper D,
Carr A,
Pett S,
Brew B,
Marriott D,
Mallon P, 
Winston A, Witherington C.

Comparing drug therapies for people with HIV.

A long-term follow-up protocol to evaluate the safety and long-term survival of autologous CD34+ hematopoietic progenitor cells transduced with an anti-HIV-1 ribozyme (OZ1) in patients with HIV-1 infection.

HIV Medicine, SVH.

Cooper D, Carr A, Pett S, Mallon P, Winston A,
Finlayson R, Workman C,
Bloch M,
MacFarlane R.

Looking at cells transduced with an anti-HIV-1 drug in patients with HIV-1 infection.

A non-interventional descriptive de-identified study of ventilation and weaning practices in Australia and New Zealand: a comparison with international practice.

Intensive Care, SVH.

Breeding J, Nair P, Presneill J, Cade J, Nelson S, Rose L.

Study of ventilation and weaning practices in intensive care units in Australia and New Zealand.

Percutaneous endoscopic gastrectomy in elderly demented patients.

Sacred Heart Hospice.

Jahromi S,
Brennan N.

Percutaneous endoscopic gastrectomy in elderly demented patients.

Brachytherapy utilisation in New South Wales in 2003: a pattern of care study.

Radiation Oncology, SVH.

Thompson S.

Investigating the use of brachytherapy in NSW.

A comparative study of HIV antibody positive patients in Ireland and New South Wales, Australia.

HIV Immunology, SVH.

Cooper D,
O'Connor M.

Comparing HIV antibody positive patients in Ireland and New South Wales, Australia.

Evaluation of newly introduced insulin chart and its effect on insulin management.

Diabetes Centre, SVH.

Welch S, Lehnbom E, Bryant W,
Ludington J, Brien J.

Evaluation of newly introduced insulin chart and its effect on insulin management.

Linguistic validation questionnaires.

Clinical Trials Centre, SVH.

Day R, Liauw W.

Linguistic validation questionnaires.

Project by working party on common reference intervals of the AACB and RCPA.

Chemical Pathology, SVH.

Jones G.

Investigating common reference intervals used in blood testing.

Leg ulcer management in the community: identifying community nurses' knowledge and practice.

St Vincent's Community Health Centre, SVH.

Shelton L.

Identifying community nurses' knowledge and practice concerning leg ulcer management.

Effects of Sildenafil on TPG in patients with pulmonary hypertension awaiting heart transplant.

Heart Transplant Unit, SVH.

Jabbour A.

Effects of a new drug on the pressure in the heart in patients with pulmonary hypertension, who are awaiting a heart transplant.

A comparison of two echocardiographic techniques for the measurement of cardiac output.

Cardiology, SVH.

Jackson A.

Comparing different techniques for measuring how much blood is ejected from the heart.

Paget's Disease treatment audit.

Garvan Institute.

Eisman J.

Undertaking an audit of treatments for the bone disorder, Paget's Disease.

Prognosis of uveitis associated with corticosteroid-induced ocular hypertension.

St Vincent's Clinic.

McCluskey P,  Leong J.

Prognosis of eye infection associated with corticosteroid-induced increased pressure in the eye.

Evaluation of learning in a video game designed to improve self-care during treatment for cancer.

Medical Oncology, SVH.

Beal I, Dalley D, Macdonald M, Dodds T, Shepherd L.

Evaluation of learning after using a video game designed to improve self-care during treatment for cancer.

Usefulness of Procalcitonin for the diagnosis of infection in neurosurgical
and neurotrauma patients.

Intensive Care, SVH.

Ben-Menachem E.

Investigating the effectiveness of Procalcitonin in diagnosing infection in neurosurgical and neurotrauma patients.

Impact of short-term low dose glucocorticoids on protein metabolism.

Garvan Institute.

Ho K, Burt M, Peris, Hansen.

Impact of short-term low dose steroids on protein metabolism.

Blood donor study in patient taking Coumadin or Warfarin.

Victor Chang Cardial Research Institute.

Graham R,
Kovacic J.

Blood donor study in patient taking Coumadin or Warfarin.

The role of CITED2 in human congenital heart disease.

Victor Chang Cardial Research Institute.

Dunwoodie S.

Investigating the role of a gene in human congenital heart disease.

Defining interactions between anabolic and peptide hormones: requirements for a robust test for growth hormone doping. A study extension.

Garvan Institute.

Ho K.

Developing a test for growth hormone doping.

Thrombotic activities of scelosants: effects on coagulation, red cells and platelets.

Haematology, SVH.

Parsi K.

Effects of a treatment on blood clotting, red cells and platelets.

Follow-up serial infusions of Natrecor (nesiritide) for the management of patients with heart failure (FUSION II).

Cardiology, SVH.

MacDonald P, 
Keogh A, 
Kottler E.

Testing of a new drug in the management of patients with heart failure.

B-blockers and lung function in heart failure.

Cardiology, SVH.

Hayward C, 
Macdonald P, 
Keogh A, Kotylar E.

Investigating beta blockers and lung function in heart failure.

The clinical correlations of Lopinavir through plasma concentrations with adverse events and concomitant medication use.

National Centre for HIV Epidemiology & Clinical Research.

Cooper D, Winston A,
Kakoma M, Mallon P,
Carr A, Ray J,  Carey D, Marriott D, Hillman R.

Investigating the blood levels of a drug and related adverse events.

Severe hyperlactataemia and lactic acidosis in HIV-infected patients with antiretroviral therapy: an international case-control study.

HIV Medicine, SVH.

Mallon P, Arenas-Pinto A, Cooper D, Carr A,
Law M.

An international case-control study looking at high levels of lactic acid in people with HIV receiving drug therapy.

A three-year, randomised, open-label, multi-centre, investigator-driven study comparing de novo enteric coated Mycophenolate Sodium with delayed onset everolimus, both arms in combination with Cyclosporin (using C2 monitoring) and corticosteroids for the prevention of bronchiolitis obliterans syndrome in heart-lung, bilateral lung and single lung transplant recipients.

Heart & Lung Transplant, SVH.

Glanville A,
Malouf M, 
Aboyoun C,
Plit M.

Comparing two drugs that prevent rejection in patients that have had a lung transplant.

A proof of concept single-blind, multi-centre evaluation of the potential beneficial effects of Mirtazapine when combined with Zonisamide for the treatment of obstructive apnoea. 

Sleep Unit, SVH.

Jenkelson D.

Comparing two drugs in the treatment of sleep apnoea.

Rosacea associated cutaneous hyperthermia controlled by vascular laser therapy.

Dermatology, SVH.

Parsi K, Whitfield M, Fisher J, Leow LJ.

Testing the treatment of rosacea using laser therapy.

A multi-centre, prospective, randomised, Phase III study to compare efficacy and safety of high dose immunoablation and autologous hematopoietic stem cell transplantation with intravenous pulse therapy cyclophosphamide, for the treatment of patients with severe systemic sclerosis. 

Haematology, SVH.

Moore J,
Dodds A,
Milliken S,
Ma D.

Comparing two treatment regimes for patients with severe systemic sclerosis.

A multi-centre, Phase III, open-label, randomised study in patients with advanced follicular lymphoma evaluating the benefit of maintenance therapy with Rituximab after induction of response with chemotherapy plus Rituximab in comparison with no maintenance therapy. PRIMA study

Haematology, SVH.

Dodds A,
Fay K,
Moore JD,
Milliken S.

Testing whether it's better for patients with advanced follicular lymphoma to continue to take Rituximab after chemotherapy or not.

Valcyte in cytomegalovirus (CMV) disease  treatment of solid organ recipients (VICTOR).  

Lung Transplantation, SVH.

Glanville A, Malouf M, Grattan A, Havryk A,
Plit M.

Testing an antivirus drug in CMV-disease treatment of solid organ recipients.

Hodgkin’s lymphoma in HIV infected patients: an inter cohort nested case-controlled study.

Immunology B Clinic, SVH.

Carr A, Bonnet F,
Law, Petoumenos K.

Investigating Hodgkin’s Lymphoma in patients with HIV.

A Phase II study of Rituximab for the treatment of Sjogren’s Syndrome.

Immunology B Clinic, SVH.

Carr A, Breit S, Kelleher A, McCluskey P, Sheridan B, Cooper D, Foltyn P.

Testing the use of Rituximab for the treatment of Sjogren’s Syndrome.

Safety and tolerability of the Japanese encephalitis vaccine IC51 (JE-PIV).  Double-blind, randomised, placebo-controlled, Phase III study. 

Clinical Trials Centre, SVH.

Marriott D.

Safety and tolerability of the Japanese encephalitis vaccine.

Long-term, immunogenicity of the Japanese encephalitis vaccine IC51 (JE-PIV). An open, uncontrolled, Phase III, follow-up study (IC51-303).

Clinical Trials Centre, SVH.

Marriott D.

Long term follow-up of the Japanese Encephalitis Vaccine.

Treatment of patients with post-transplant lymphoproliferative disorder (PTLD) with a sequential treatment consisting of anti-CD20 antibody Rituximab and CHOP plus GCSF chemotherapy.

Haematology and Heart & Lung Transplant, SVH.

Moore J,
Glanville A,
Macdonald P, Ma D, Milliken S, Dodds A.

Treatment of patients with post-transplant lymphoproliferative disorder with a sequential treatment.

Linking the IL-7/R system to B and T-cell neoplastic events (LINE).

Immunology, SVH.

Kelleher T, Milliken S, Moore J, Sasson S,
Smith S, Zaunders J.

Linking the IL-7/R system to B and T-cell neoplastic events.

Phenotyping of vascular dendritic cells in atherosclerotic plaques (with special attention in rupture-prone regions).

Senior Professorial Unit, SVH.

Lord R, Bobryshev Y, Grabs A, Tran D.

Identifying vascular cells in atherosclerotic plaques, with special attention in rupture-prone regions.

Herb-drug interactions with hypoglycaemic medicine.

Clinical Trials Centre, SVH.

McLachlan A, 
Williams K, Liauw W,
Day R, Jiang X, Xu H.

Analysing herb-drug interactions with hypoglycaemic medicine.

A Phase III, 12-week, multi-centre, double-blind, double-dummy, randomised, placebo and active comparator, parallel-group study to investigate the efficacy and safety of GW406381 1mg, 5mg, 10mg, 25mg and 50mg administered orally once daily, in adults with osteoarthritis of the knee.

Clinical Trials Centre, SVH.

Day R,
Liauw W,
Williams K.

Comparing different doses of a drug in the treatment of osteoarthritis of the knee.

A randomised, double-blind study of GT267-004 versus Vancomycin and GT267-004 versus Metronidazole in patients with C Difficile-associated diarrhoea.

Clinical Trials Centre, SVH.

Harkness J,
Marriot D,
Liauw W,
Davis R.

Comparing different drug regimes in the treatment of C Difficile-associated diarrhoea.

A randomised, placebo-controlled, parallel group, single dose study of SB-681323 in patients with active rheumatoid arthritis to investigate the CRP dose response relationship.

Clinical Trials Centre, SVH.

Day R,
Liauw W,
Williams K.

Testing a new drug in the treatment of people with rheumatoid arthritis.

Immunogenicity of the inactivated, split-virion influenza vaccine, southern hemisphere 2005 formation (intramuscular route).

Clinical Trials Centre, SVH.

Day R,
Liauw W,
Williams K.

Testing the effectiveness of the flu vaccine.

A Phase II, open-label, multi-centre study evaluating Ambrisentan in subjects with pulmonary arterial hypertension who have previously discontinued endothelin receptor antagonist therapy due to serum aminotransferase abnormalities.

Heart Lung Transplant, SVH.

Keogh A,
Macdonald P, 
Kotlyar E,
Hayward C,
Brown K.

Evaluating a drug used to treat pulmonary hypertension.

Maintenance antiretoviral therapy for late cytomegalovirus (CMV) reactivation following unrelated allogenic haematopoietic stem cell transplantation (HSCT).

Haematology, SVH.

Dodds A,
Ma D,
Moore J,
Milliken S,
Fay K.

Maintenance antiretoviral drug therapy for late CMV infections following unrelated stem cell transplantation.

A double-blind, randomised, placebo-controlled study to evaluate the safety and efficacy of A60444 in adults with respiratory syncytial virus (RSV) infection following stem cell transplantation.

Haematology, SVH.

Dodds A,
Moore J,
Milliken S,
Ma D, Fay K.

Testing of a new drug for treating an infection following stem cell transplantation.

A Phase III, randomised, double-blind, placebo-controlled study to evaluate the efficacy and safety of weekly doses of Palifermin (recombinant Human Keratinocyte Growth Factor, rHuKGF) for the reduction or oral mucositis in subjects with advanced head and neck cancer receiving adjuvant radiotherapy and chemotherapy.

Medical Oncology / Radiation Oncology, SVH.

Dalle D,
Ward R,
Grygiel J,
Segelov E,
Stylian S,
Cooper S,
Jagavkar R,
Chen C.

Testing a drug regime to treat infection in the mucosal lining of the gastrointestinal tract in subjects with advanced head and neck cancer, receiving both radiotherapy and chemotherapy.