| Research project |
Institution on whose behalf the
research is being undertaken |
Researcher |
Description |
| Molecular mechanisms of wound healing. |
Department of Haematology, SEALS; Department of
Plastic Surgery, St George Hospital. |
Lindeman R,
Roman S,
Poole M J.
|
This project looks at the sequence of
events leading to the healing of wounds in a rat flap model. We have
used a gene therapy approach to alter the levels of some
substances in order to investigate this process further. |
| Randomised, parallel-arm, equivalence
study comparing Hydromorphone Hydrochloride extended-release (HHER)
capsules with Ms Contin tablets, at a dose ratio of 1:7.5, in
cancer or non-cancer patients with a history of moderate to
severe pain. |
Department of Haematology, SEALS; Diabetes Transplant Unit, Prince of Wales Hospital. |
Lindeman R,
Tuch
B,
Palma C.
|
Immature cells from cord blood, bone
marrow and peripheral blood can differentiate into a variety of
cell types. The aim of this project is to determine whether
a combination of cell culture conditions and the insertion of
genes important in the development of the pancreas can produce
pancreatic properties in these cells. |
| Identification of a genetic abnormality
responsible for the veno-occlusive and immunodeficiency
syndrome. |
Molecular and Cytogenetics Unit and
Department of Haematology, SEALS. |
Buckley MF,
Roscioli T,
Lindeman R,
Ziegler J,
Kirk E, Cliffe S, Donald J. |
The genetic abnormality responsible for
a syndrome of immunodeficiency and a predisposition to veno-occlusive
disease has been identified in several kindreds. Abnormalities
of the gene are being sought in other individuals with
immunodeficiencies. |
| Biological markers in DCIS of the
breast. |
Anatomical Pathology, SEALS; Cancer
Care Centre, St George Hospital. |
Millar EKA,
Graham P. |
Identification of tissue-based
predictors of response to treatment and prognosis. |
| Acanthamoeba keratitis – review of NSW
cases 1997-2002. |
Department of Microbiology, SEALS. |
Butler TKH, Males JJ, Robinson LP,
Wechsler AW, Sutton GL,
Cheng J,
Taylor PC, McClellan K. |
Detection of protozoon (Acanthamoebae)
from infected eyes and contact lens of patients that have been referred to
Sydney Eye Hospital. |
| Laboratory proficiency in testing for
Burkholderia cepacia. |
Department of Microbiology, SEALS. |
Taylor P, McLaws M,
de Borde M,
Pritchard R. |
Isolation and identification of
Burkholderia cepacia by participants in an external quality
assurance program between 1994 and 1999. |
| Direct detection of Staphylococcus
aureus from blood cultures. |
Department of Microbiology, SEALS. |
Varettas, K, Mukerjee C, Taylor P. |
Looking at a new process for detecting
Staphylococcus aureus as anticoagulant carryover may influence
clot formation in direct tube coagulase tests from blood
cultures. |
| Serological response to Meningococcal
vaccine (Group C). |
Department of Microbiology, SEALS. |
Robertson PW, Taylor P,
Fyfe D,
Tapsall J. |
Assessment of vaccination response by
rise in antibody levels. |
| Heparin induced Thrombocytopenia (HIT)
testing. |
Department of Haematology/ Coagulation, SEALS. |
Gemmell R. |
Establishing screening testing for
patients whose platelet count drops while on heparin, using a
particle gel immunoassay kit from DiaMed, and the sensitivity,
specificity and negative predictive value of the test as
compared with Serotonin release tests offered by SEALS. |
| Platelet Factor 3 availability. |
Department of Haematology/ Coagulation, SEALS. |
Gemmell R. |
Investigating other test methods to
detect Platelet Factor 3 availability compared with our current
manual method. |
| Use of platelet function testing by
whole blood platelet aggregation (WBPA) to monitor anti-platelet
medication and its efficacy. |
Department of Haematology/ Coagulation and the
Department of Clinical Haematology, SEALS. |
Gemmell R
(with Prof Manoharan). |
Using WBPA in patients on aspirin,
garlic and clopidogrel to determine if the dose of anti-platelet
medication is adequate. |
| Platelet function testing using the
Platelet Function Analyser (PFA) from Dade. |
Haematology / Coagulation, SEALS. |
Gemmell R. |
Use of PFA as a screening test for
platelet function. |
| Detection and epidemiology of enteric
viruses. |
Department of Microbiology, SEALS; UNSW. |
McIver,
White,
Tu,
Bull,
Hanson, Rawlinson. |
Development of molecular methods and
surveillance of genotypes of norovirus and sapoviruses in
Sydney. |
| Detection of agents associated with
congenital infections. |
Department of Microbiology, SEALS; UNSW. |
McIver,
Jacques,
Chow,
Munro, Rawlinson. |
Development of multiplex polymerase
chain reaction for detection of agents of congenital infections. |
| Molecular detection of viral pathogens. |
Department of Microbiology, SEALS. |
McIver C, Rawlinson W. |
Development of multiplex polymerase
chain reaction for detection of intestinal parasites including G
lambia, D fragilis, Cryptosporidia and E histolytica. |
| DNA polymerase modelling of human
cytomeglovirus (HCMV) and murine cytomeglovirus (MCMV) by using
in-silico and protein crystallography techniques. |
Virology Research Laboratory, SEALS; St
Vincent’s Institute. |
Morton, Rawlinson,
Scott,
Miles,
Iwasenko. |
Determining whether conformational change
of the polymerase affects antiviral resistance. |
| Modelling of the UL97 gene (protein
kinase) of human cytomeglovirus (HCMV) and murine cytomeglovirus
(MCMV) as well as other cytomeglovirus (CMV) proteins. |
Virology Research Laboratory, SEALS; St
Vincent’s Institute. |
Morton, Rawlinson,
Scott,
Miles,
Iwasenko. |
Determining whether conformational change
of the protein kinase and other CMV proteins affect antiviral
resistance |
| Quantify the activity of the wild type
and mutated DNA polymerase using DNA polymerase activity assays. |
Virology Research Laboratory, SEALS. |
Iwasenko, Rawlinson,
Scott,
Miles. |
Mutated cytomeglovirus (CMV)
polymerases may have an unusual rate of synthesis compared to
wild type CMV polymerases which contribute to antiviral
resistance. |
| Determine the role of UL44 (accessory
protein) and UL102 (primase / helicase protein) of CMV in
antiviral resistance. |
Virology Research Laboratory, SEALS. |
Iwasenko, Rawlinson,
Scott,
Miles,
Yiu. |
The accessory protein and the primase / helicase
protein are important in DNA synthesis and may be involved in
antiviral resistance. |
| Determine the prevalence of
cytomeglovirus (CMV) and other viral agents in liver transplant
cohorts. |
Virology Research Laboratory, SEALS;
Austin Hospital, Melbourne; Royal Prince Alfred Hospital,
Camperdown. |
Scott,
Rawlinson, Iwasenko,
Miles. |
The presence of specific viruses in the
blood or tissue may affect the success of a liver transplant. |
| Determine the prevalence of
cytomeglovirus (CMV) and other viral agents in renal transplant
cohorts. |
Virology Research Laboratory, SEALS;
Virology Diagnostic Laboratory, Prince of Wales Hospital. |
Scott,
Rawlinson, Iwasenko, Rismanto. |
The presence of specific viruses in the
blood or tissue may affect the success of a renal transplant. |
| Detection of specific viral loads in
solid organ transplantation and its correlation to clinical
outcomes. |
Virology Research Laboratory, SEALS;
Virology Diagnostic Laboratory, Prince of Wales Hospital; Royal
Prince Alfred Hospital, Camperdown; Austin Hospital, Melbourne. |
Scott,
Rawlinson, Iwasenko, Rismanto. |
Viral loads may lead to an increase in
solid organ transplantation rejection therefore, determining
viral loads may be helpful in formulating clinical algorithms. |
| Detection of cytomeglovirus (CMV)
genotypes that confer antiviral resistance in liver and renal
transplant patients. |
Virology Research Laboratory, SEALS. |
Iwasenko,
Scott,
Rawlinson, Rismanto. |
Specific genotypes may be involved in
antiviral resistance in liver and renal transplantation and may
assist in clinical algorithms. |
| Genotyping of the human Cytomegalovirus
(HCMV) in liver and renal transplantation events. |
Virology Research Laboratory, SEALS. |
Iwasenko, Scott, Rawlinson, Miles,
Rismanto. |
Specific HCMV genotypes may be
predominant during liver and renal transplantation events. |
| Determine the presence of human
cytomeglovirus (HCMV) and other herpes viruses such as human
herpes virus (HHV) 6, 7 and 8 during renal and liver
transplantation events. |
Virology Research Laboratory, SEALS. |
Miles,
Scott, Rawlinson, Iwasenko, Rismanto. |
HHV 6, 7 and 8 may play a role in
transplant rejection due its presence in a co-infection with
human cytomeglovirus (HCMV). |
| Comparative methological study of human
cytomeglovirus (HCMV) viral loads which confer antiviral
resistance. |
Virology Research Laboratory, SEALS. |
Gunawan,
Scott, Rawlinson, Iwasenko. |
Viral loads of HCMV conferring
antiviral resistance will be assessed using light cycler methods
and phenotypic assays |
| Novel compounds derived naturally will
be assessed for anti human cytomeglovirus (HCMV) activity. |
Virology Research Laboratory, SEALS;
University of Central Florida, USA. |
Miles,
Scott,
Gunawan,
Miles, Rawlinson, Iwasenko. |
Compounds that were derived from
tropical sources were tested in a phenotypic assay to determine
possible activity against HCMV. |
| Determine possible anti human
cytomeglovirus (HCMV) activity using novel synthetic compounds. |
Virology Research Laboratory, SEALS. |
Carroll,
Scott,
Gunawan, Rawlinson. |
Compounds that were derived
synthetically were tested in a phenotypic assay to determine
possible activity against HCMV. |
| Detection of novel DNA polymerase
mutations from human cytomeglovirus (HCMV) that confer antiviral
resistance. |
Virology Research Laboratory, SEALS. |
Scott,
Rawlinson, Iwasenko. |
The detection of novel DNA polymerase
mutations that may confer antiviral resistance by using
sequencing may assist in clinical algorithms. |
| Characterisation of murine
cytomeglovirus (MCMV) DNA polymerase mutations that may confer
antiviral resistance. |
Virology Research Laboratory, SEALS. |
Scott,
Rawlinson. |
DNA polymerase mutations in MCMV may be
analogous to mutations in human cytomeglovirus (HCMV) which
confer antiviral resistance. |
| Use of an in vitro model to acquire
mutations in the DNA polymerase of human cytomeglovirus (HCMV)
that confer antiviral resistance. |
Virology Research Laboratory, SEALS. |
Iwasenko,
Scott,
Rawlinson. |
Continuous passaging of HCMV in cell
culture may assist in determining the chronological accumulation
of DNA polymerase mutations that confer antiviral resistance. |
| Detection of antiviral resistance
during infection with herpes simplex viruses (HSV). |
Virology Research Laboratory, SEALS. |
Miles,
Scott,
Rawlinson. |
Long term therapy with antiviral may
lead to resistance by HSV. |
| Genotype shifting of human
cytomeglovirus (HCMV) in cell tropism studies. |
Virology Research Laboratory, SEALS. |
Woon,
Scott,
Rawlinson. |
Genotypic predominance of HCMV may
shift during infection and may assist in clinical algorithms. |
| Determine specific cell tropism for
human cytomeglovirus (HCMV). |
Virology Research Laboratory, SEALS. |
Woon,
Scott,
Rawlinson. |
HCMV has a broad range of tissues that
it may infect and this knowledge would be helpful in determining
defined pathogenic mechanisms of infection. |
| Detection of human cytomeglovirus (HCMV)
in dried blood spots from congenital infections. |
Virology Research Laboratory, SEALS. |
Brennan, Rawlinson. |
HCMV is the leading cause of congenital
infections and its prevalence in the blood of infants has not
been assessed thoroughly to date. |
| Correlative study to determine the
relationship between stillbirths and HCMV infection. |
Virology Research Laboratory, SEALS. |
Hall,
Jacques,
Chow,
Koelsch, Rawlinson. |
HCMV has been previously discovered as
having an association with stillbirths but the correlation has
not been studied. |
| T cell association with human
cytomeglovirus (HCMV) and stillbirths. |
Virology Research Laboratory, SEALS. |
Hall,
Jacques,
Chow,
Koelsch, Rawlinson. |
T cell involvement has been implicated
during HCMV infection but its role in contributing to
stillbirths is not known. |
| Human cytomeglovirus (HCMV) tropism of
synctiotrophoblasts. |
Virology Research Laboratory, SEALS. |
Hall,
Jacques,
Chow,
Koelsch, Rawlinson. |
The determination of how HCMV causes
infection by determining the cells in which it infects is
important in determining pathogenic mechanisms of infection.
Synctiotrophoblasts are important cells for the entry of virus
into the placenta and therefore infect the foetus. |
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