| Research project |
Institution on whose behalf the research is being undertaken |
Researcher |
Description |
Allied Health
Dietetics
|
| Evaluation of a
family-based weight management program in a paediatric
outpatient setting. |
Sydney
Children’s Hospital Foundation. |
Katz T,
Aitken
M,
Jackson R,
Neville K. |
This study aims
to determine whether group education of parents of overweight
children
by a dietician and a clinical psychologist, is a
successful management strategy when compared with traditional
one-on-one consultations by a dietician alone. |
Occupational Therapy
|
| Accessible
toilet facilities for children and adolescents: enhancing the
evidence base. |
Sydney
Children’s Hospital Foundation. |
Kingsley A,
Croudace S. |
Study to
determine whether toilets built for use by those with a physical
disability are accessible to the majority of children and
adolescents with physical disabilities aged 4 to 18 years. |
Physiotherapy
|
| Inter-rater
reliability of physiotherapists using the Pirani assessment of
congenital talipes equinovarus. |
Sydney
Children's Hospital (SCH). |
Harvey N,
Sims
S,
Mudge A. |
Study to
ascertain the reliability of a club foot assessment tool when used
between physiotherapists, and / or by one physiotherapist on
more than one occasion. |
Psychology
|
| Social skills
groups for children with traumatic brain injury. |
Motor Accidents
Authority of NSW. |
Brookes N,
Epps
A. |
Development and
evaluation of a school-based social skills group intervention
for children with social difficulties following a traumatic
brain injury. |
Frequency of
emotional and behavioural symptomatology in children with
acquired brain
injury at a specialist paediatric unit. |
University of Sydney;
SCH. |
Soo C,
Tate R,
Brookes N. |
Examination of
the frequency and nature of behavioural and emotional problems
following acquired brain injury in an Australian paediatric
population |
| Predictors of
sibling adjustment following a child traumatic brain injury. |
University of
Sydney; SCH. |
Lah S,
Sambuco
M, Brookes N,
Hunt C. |
Study
identifying core factors influencing sibling adjustment in
families of children with traumatic brain injury. |
| The development
of a sleep disturbances scale for children aged 2 to 5 years. |
Charles Sturt
University; University of NSW School of Psychology; SCH. |
Dryer R,
Kiernan M,
Betts G, Teng A, MacGregor F, Williamson B. |
This study aims
to develop a psychometrically valid questionnaire to detect
sleep disturbances in young children, and to examine the
relationship between parent behaviours used to settle children
to sleep and sleep disturbance. |
| The development
of a scale to assess the impact of chronic paediatric pain on
school functioning |
SCH. |
Piira T,
Betts
G, McInerney M, Chan E,
Crawford M, Workman T, Champion D. |
This study aims
to develop the first psychometrically reliable and valid school
function questionnaire for chronic pain patients. |
| The cognitive
effects of early onset versus late onset juvenile
insulin dependent diabetes mellitus. |
SCH. |
Betts G,
Verge
C,
Lynch R,
Bennett N, Frilingos M. |
This study
compares children with early versus late onset diabetes on
cognitive function and follows them longitudinally for three years.
It also examines the potentially cumulative and interactive
effects of early versus late onset dependent diabetes and blood glucose control (high versus
low levels) over time. |
Centre for Children's Cancer & Blood Disorders
|
| Biology study
for Neuroblastoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Neuroblastoma is a
tumour of nerve cells usually found in the abdomen, chest or
neck of young children. The research of this study is to define
the characteristics of this disease and to predict the best
therapy for each child. |
| A study using
drugs and stem cell transplantation in children with juvenile
myelomonocytic leukemia (JMML). |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
JMML is a rare
form of leukemia usually found
in children no older than 5
years. The purpose
of this study is to find out what effects a
new treatment program has on JMML. |
| Treatment of
newly diagnosed lymphoblastic lymphoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Lymphoblastic
lymphoma is a
cancer of the lymph system. This study compares four
chemotherapy treatments. |
| Protocol for
treatment of children with hepatoblastoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study uses
a drug which could help protect normal cells from chemotherapy
and stop some of the side effects that often occur following the
chemotherapy treatment of hepatoblastoma. |
| Chemotherapy,
surgery and radiation therapy for children with non-metastatic
brain tumour. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Non-metastatic
brain tumour is a type of cancer in the central nervous system
(brain and spinal cord). This research investigates if this
treatment will help improve the cure rate for young children
with brain tumour that has not spread beyond the primary site. |
| Therapy for
children and adolescents with newly diagnosed intermediate risk
Hodgkin Disease. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study uses
drugs (chemotherapy) and high-dose x-rays (radiation therapy)
and examines the negative effects from the treatment later in
life. |
| Treatment for
children with refractory meningeal malignancies. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
The purpose of
this study is to find out what effects an anti-cancer drug has
when given directly into the cerebrospinal fluid in children and
adolescents with neoplastic meningitis (cancer that has spread
to the lining of the brain and spinal cord). |
| Treatment of
advanced-stage anaplastic large cell lymphoma (ALCL). |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study is
designed for patients less than 21 years old with ALCL, a cancer
of the lymphatic tissue. |
| Therapy in the
treatment of children with low and intermediate risk germ cell
tumours. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Germ cell
tumours are a type of cancer found
in the ovaries or testes.
This tumour may also
be found in other areas of the body such as
the brain, chest or abdomen. |
Chemotherapy in
children with recurrent/refractory
B-cell non-Hodgkin lymphoma and B-cell acute lymphoblastic
leukemia. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
involves a new drug in an attempt to improve the survival of
patients with these types of cancer that have not responded well
to standard treatment. |
| Study for
children with refractory/relapsed Hodgkin Disease. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
The major goal
of this study is to look at how patients with Hodgkin Disease
that has come back and/or become resistant to standard treatment,
respond to a new treatment. |
| National Wilms
tumour late effects study. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
The purpose of
this research is to learn more about the causes of Wilms tumour
and the effects of treatment for Wilms tumour. Children are
evaluated on a long-term basis to monitor long-term effects from
their treatment. |
| Study involving
children with chronic myelogenous leukemia. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Chronic
myelogenous leukemia is a specific kind of leukemia (blood
cancer) that is associated with the presence of an abnormal
chromosome. This study tests the safety and effectiveness of
a
new drug for this cancer. |
| A study for
collecting and/or banking research specimens. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Cancer samples
are collected and kept in a tissue bank with the aim of learning
more about cancer and how to prevent, stop it from spreading to
other parts of the body, and cure it. |
| Surgery for
low-risk neuroblastoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
A study to
determine if low risk patients can be treated with surgery only,
avoiding the side effects of chemotherapy, as recent experience
indicates that chemotherapy may not be needed. |
| Treatment for
infants and children with intermediate risk neuroblastoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
involves anti-cancer medicines (chemotherapy) with the purpose of
investigating if less anti-cancer treatment can be used and still
cure most children with this cancer. |
| Chemotherapy
for astrocytoma in children less than ten years old. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This brain
tumour study investigates whether chemotherapy can substitute
radiation in children in whom the risk of side effects from
radiation is higher. |
| Study for
patients with intermediate risk rhabdomyosarcoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Rhabdomyosarcoma is a type of soft tissue tumour. This study
determines if substituting a new drug in place of a currently
used drug will improve the cure rate. |
| Study for
children with recurrent or progressive brain tumours. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
tests an experimental drug to find
out its effect in patients with recurrent or progressive (the tumour has
come back or
has become worse after standard therapy) childhood brain
tumours. |
| Trial for
children with Ewings sarcoma and related tumours. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Ewings sarcoma
is a type of cancerous tumour that forms in the bone or soft
connective tissues. These tumours spread quickly to other areas
of the body including the lungs, other bones, bone marrow and
the brain. This research is being undertaken to determine if a new method
can cure more patients. |
| Therapy for
newly diagnosed low-risk patients with embryonal/botryoid
rhabdomyosarcoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
determines the most effective and least toxic chemotherapy for
patients with a
low risk of the disease recurring. |
| Therapy for
selected children and adolescents with newly diagnosed
rhabdomyosarcoma. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
involves metastatic tumours, that is a tumour that has already
invaded other tissues in the body. |
| A study for the
treatment of children with refractory or relapsed solid tumours. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
examines the effects that the study drug has on certain tumours that
occur in children and young adults. |
| Study in
children with refractory leukemias. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
tests the use of a new drug for the treatment of children with
refractory leukemia - leukemia that does not respond to standard
treatment. |
| Trial for
children with solid tumours. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
involves a type of cancer which has continued to grow despite
treatment with standard therapy. |
| Treatment of
patients with brain tumours. |
St Jude
Hospital, Memphis, USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study uses
new molecular tests to analyse tumours in the hope of coming up
with tumour “profiles” that can predict how tumours might
respond to therapy. Using this information, physicians may be
able to tailor future therapies for individual tumour types,
which may increase the possibility of treatment success |
| Australian
study of causes of acute lymphoblastic leukemia in children (AUS ALL). |
Telethon
Institute of Childhood Health Research, Western Australia. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
The aim of the
study is to investigate genetic, dietary and environmental
causes of acute lymphoblastic leukemia. |
| Dual combined
umbilical cord blood transplantation in life threatening
diseases. |
SCH. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This
study investigates the effectiveness of combining two cord blood
units for use in transplant for children with life-threatening
diseases of the blood and bone marrow. |
| Study of acute
lymphoblastic leukemia in children (ALL STUDY 8 PILOT). |
Australian &
New Zealand Children’s Haematology/Oncology Group. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
The purpose of
this study is to identify children who have a lower chance of
cure with standard acute lymphoblastic leukemia treatments and use a new intensified
treatment (radiotherapy and chemotherapy) to attempt to increase
their chances of long term cure. The study also uses laboratory
tests to detect very small amounts of leukaemia . |
| Treatment of
lymphoma/leukemia. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
This study
examines if a new treatment is better than treatments used in
the past and to find out the side effects of treatment.
Follow-up only. |
| National Wilms
tumour study 5: therapeutic trial and biology study. |
Children’s
Oncology Group USA. |
Marshall G,
Cohn R,
Russell S,
O’Brien T. |
Wilms tumour is
a rare tumour that occurs in children and is treated with a
combination of surgery, chemotherapy and in some cases
radiotherapy. Follow-up only. |
| Evaluation of
the therapeutic efficacy and mechanisms of a novel treatment for
childhood neuro-blastoma combining Histone Deacetylase
Inhibitors, 13-cis retinoic acid and interferon-alpha. |
Sydney
Children’s Hospital Foundation. |
Marshall G,
Nguyen T. |
A
laboratory-based study looking at a potential new therapy for
this form of childhood developmental tumour. |
| Complementary
and alternative therapies in paediatric oncology: identifying
psychological correlates of use. |
Sydney
Children’s Hospital Foundation. |
Goodenough B. |
Exploring
predictors of parent's use and interest in non-conventional
treatments for children with cancer. |
Children’s
understanding of pain, fatigue and nausea: a priority for
symptom measurement
and management. |
University of NSW. |
Goodenough B. |
Investigating
children’s understanding of the causes of their symptoms and
relationship to intensity ratings. |
| Long-term
adjustment in survivors of childhood cancer and their parents
and siblings. |
University of
NSW; SCH. |
Suneson B,
Goodenough B, Cohn R,
Johnston K. |
Documenting
prevalence of stress and thriving outcomes after childhood
cancer cure in family members. |
| KidCom: linking
home and hospital. |
Baxter Medical
Trust. |
Goodenough B,
Cohn R. |
Field trial of
webcam-based communication for reducing psychosocial distress in
families separated by hospitalisation. |
| Hoping and
coping with cancer: cognitive behavioural therapy for children
and adolescents with leukaemia. |
University of
Sydney; NHMRC. |
Pritchard M,
Butow P,
Stevens M, Goodenough B, Cohn R. |
Investigating
the
effectiveness of an individual cognitive behavioural program for
improving children’s illness perceptions, coping and treatment
adherence in acute lymphoblastic leukaemia. |
| Paediatric
oncology end-of-life context: the basis and impact of the
decision to die at home. |
SCH. |
Drew D,
Goodenough B. |
Retrospective
investigation of decision-making and palliative care experienced
in parents who have lost a child to cancer. |
| Telephone
support group for bereaved parents. |
SCH. |
Nair K,
Goodenough B. |
Evaluating the
efficacy and acceptability of post-bereavement support by
teleconferencing to isolated families. |
| Measuring
nausea in children 4-7 years of age. |
SCH. |
Senner A,
Crisp
J. |
Eliciting
descriptions of nausea from children, their parents and health
care professionals as the first stage of developing a
measurement tool for children in this age group undergoing treatment for cancer. |
| A comparison of
the survival rates of all adolescents and young adults diagnosed
with cancer in NSW between 1993 and 2001, in relation to whether
they were treated in an adult or paediatric facility. |
Cancer Council
NSW; SCH. |
Senner A,
Marshall G, O’Connell D, Carroll S,
O’Brien T. |
Comparing the
survival statistics of adolescents with cancer by whether they
were treated in an adult or paediatric facility. |
Endocrinology
|
| Pathophysiology
and prevention of post-operative hyponatraemia in children. |
Sydney
Children’s Hospital Foundation. |
Walker J,
Neville K, Sandeman N. |
Hyponatraemia,
or low blood salt levels, are common in children and adults in
hospital, particularly after surgery. This prospective
randomised study is examining the hormonal and biochemical
changes that may predispose some children to developing this
problem. |
Emergency
|
| Screening for
urinary tract infection in children. |
SCH. |
Wilson L,
O’Meara M. |
Identification
and implementation of the most timely and cost-effective method
for screening urine samples for possible infection. |
| Child
protection assessment for all infants presenting with fractures. |
SCH. |
Pennington T,
Zwi K,
Tzioumi D, Zordan R, O’Meara M,
Moran K. |
Assessment of a
strategy to improve the rate
of detection of possible
non-accidental injury
in infants presenting to the Emergency
Department. |
Executive Unit
|
| Cultural
diversity, parenting practices and health care. |
University of
Western Sydney; SESIAHS Multicultural Health Unit. |
Chalmers S,
White L. |
A study of
cultural mismatches between parents/carers and health
professionals. |
| Culturally
specific expectations for acute health services in South East
Health Multicultural Health Unit. |
SESIAHS. |
Lissing J,
Chalmers S. |
Attempt to
broaden current knowledge on how choices made by consumers of
child health services are influenced by ethnicity. |
| Negotiating the
challenge of cultural diversity in children’s health care: the
Australian context. |
Australian
Research Council. |
Chalmers S,
Ang
I,
Mason J,
Choucair S,
White L,
Lord B,
Eastwood J. |
This project is
mapping the range of cultural practices in health
service provision, providing culturally appropriate and relevant
data to inform policy, and the planning and resourcing
of health
services for parents/carers in NSW. |
| Anchoring
preventive health care to positive learning: an exploration of
local methods of organising and improving clinical practices. |
Australian
Research Council. |
Iedema R,
Braithwaite J, White L,
Williams K,
Sorensen R. |
This research
explores interaction of clinical-professional teams to assess
whether these display practical vigilance, mutual attentiveness
and innovative flexibility. |
Gastroenterology
|
| Utility of
stool markers in diagnosis of organic disease in children with
gastrointestinal symptoms. |
Sydney
Children’s Hospital Foundation. |
Day A,
Sidler
M,
Leach S. |
A prospective
study focusing on non-invasive markers of gut inflammation in
children presenting with gut symptoms. |
| Randomised,
double-blind, placebo-controlled, cross-over trial of VSL#3 in
children with Crohn’s disease. |
Sydney
Children’s Hospital Foundation. |
Day A,
Mitchell H,
Lemberg A.
|
Study to assess
the role of probiotics in active Crohn’s disease. |
| Long-term trial
of VSL#3 in Crohn’s disease in children in remission. |
SCH. |
Day A,
Lemberg
A,
Mitchell H. |
Study to assess
the role of probiotics in the maintenance of remission in quiescent Crohn’s disease. |
| Evaluation of
inflammatory markers in children with gastrointestinal symptoms. |
SCH. |
Day A. |
Examination of
novel markers of inflammation
in children with inflammatory
bowel disease. |
| Do enteral
feeds alter intestinal flora in children with Crohn’s disease? |
SCH. |
Day A. |
Prospective
study to determine the effects of enteral feeds upon the
intestinal flora in children with Crohn’s disease. |
| Natalizumab in
adolescents with Crohn’s disease. |
SCH. |
Day A,
Bohane T. |
International
multi-centre study evaluating
the safety and efficacy of Natalizumab in adolescents. |
Nationwide
assessment of disease-related knowledge in children with Crohn’s
disease and
their parents. |
The Australian
Crohn’s and Colitis Association; SCH. |
Day A. |
Surveying
children and their families to determine the level of knowledge
about the illness. |
| The role of
mucous-associated bacteria in the gut. |
SCH. |
Day A,
Mitchell
J,
Zheng L. |
A detailed
examination of the bacteria living in the mucous layer of the
gut, and the potential relevance of these organisms to gut
inflammation. |
| Validation of
S100 A12 as a faecal marker of gut inflammation. |
SCH. |
Day A,
Leach S,
deJong N. |
A study
establishing and validating a novel faecal test of gut
inflammation in children. |
| S100 proteins
in family members of children with inflammatory bowel disease. |
SCH. |
Day A,
Leach S,
Shalloo N. |
A prospective
study evaluating levels of key faecal proteins in siblings and
parents of children with known inflammatory bowel disease. |
General medicine
|
| Australian
Paediatric Surveillance Unit Study: Haemoglobinopathies
(excluding carrier states). |
SCH. |
Emder P,
Argent
E,
Mowat D, Sachdev R, Russell S, Monagle,
Stone C,
Zeigler D, Peterson T. |
A study
designed to determine the incidence of these diagnoses in the
Australian community. |
| A comparative
study of blood sample collection from peripheral intravenous
cannula device versus standard venipuncture. |
Sydney
Children’s Hospital Foundation. |
Brydon M,
Neville K,
Katf H,
Cameron P. |
This study is
to assess the reliability of basic clinical chemistry and
haematology tests taken from indwelling intravenous lines, in
order to potentially save paediatric patients the need for a
separate blood test. |
Immunology and infectious diseases
|
| Severe combined
immunodeficiency: a national surveillance study. |
Australian
Perinatal Surveillance Unit, NSW Health. |
Yee A,
Ting S,
Elliott E,
Ziegler J. |
Surveillance of
the incidence of severe combined immunodeficiency in Australia |
| The Australian
candidaemia study: a population-based laboratory surveillance. |
The Australian
Candidemia Study Group. |
Palasanthiran
P. |
This study will describe the
epidemiology
(incidence, distribution, control and prevention) of candidaemia
in adult and paediatric patients throughout Australia. |
| Surveillance of
severe food allergy in Australian children. |
CSL Limited;
Australian Perinatal Surveillance Unit, NSW Health. |
Dosen A,
Ziegler J,
Kemp A, Ruhno J, Gold M, Loh R, Peake J. |
Study of the
epidemiology (incidence, distribution, control and prevention) of allergic reactions to food requiring hospital
treatment, the causative foods, risk factors, and immediate and
long-term management. |
| Congenital
cytomegalovirus
surveillance study. |
Australian
Perinatal Surveillance Unit , NSW Health. |
Rawlinson W,
Palasanthiran P, et al. |
Surveillance
study of the incidence of congenital cytomegalovirus Australia-wide. |
| Surveillance
study of non-tuberculous mycobacterial (NTM) infection in
children. |
Australian
Perinatal Surveillance Unit, NSW Health. |
Palasanthiran
P, Best E, Blyth C, et al. |
Surveillance
study of the incidence of non-tuberculous mycobacterial (NTM) infections in children
Australia-wide. |
| Study to
investigate the cause of an inherited disorder characterised by
liver disease and immune deficiency. |
Children’s
Hospital at Westmead; SCH. |
Lindeman R,
Roscioli T,
Kirk E,
Buckley M, Ziegler J. |
Identification
of the gene which causes vaso-occlusive disease with
immunodificiency (VODI). |
| Genetics of
Kawasaki Disease. |
University of
Western Australia; SCH. |
Burgner D,
Palasanthiran P, Ziegler J. |
Study of
genetic host factors predisposing to Kawasaki’s Disease. |
| Immune
responses of pneumococcal vaccination. |
Sydney
Children’s Hospital Foundation; Canberra Hospital. |
Ziegler J,
Palasanthiran P. |
Study
investigating pneumococcal vaccine immune responses in children
previously infected with pneumococcus. |
| Decline of
transplacentally acquired maternal hepatitis C (HCV) antibodies. |
Sydney
Children’s Hospital Foundation. |
Palasanthiran
P, Ziegler J, Robertson P. |
This study
investigates the rate and pattern of decline of maternally
acquired HCV antibodies in infants born to HCV infected mothers. |
| Role of
microtransfusion in the perinatal transmission of HIV. |
Internal;
Australian Postgraduate Award
research scholarship to J Warning. |
Warning J, Ffrench R,
Ziegler J. |
Use of cellular
and genetic methods to identify maternal cells in infant blood,
seeking also evidence of immune responses to HIV in exposed,
uninfected infants. |
| Immune
responses to hepatitis C in exposed, uninfected individuals. |
Internal;
Australian Postgraduate Award
research scholarship to L Elliott. |
Elliott L,
Ffrench R,
Ziegler J,
Lloyd A. |
A study
involving serological testing and evidence of T cell immunity in
various cohorts. |
| Transplacental
transmission of viruses and pathogenesis of stillbirths,
pre-term births and congenital anomalies. |
SCH. |
Rawlinson W,
Jeffery H,
Jones C,
Craig M, Palasanthiran P. |
This
prospective study is based on the hypothesis that undiagnosed
viral infections are a cause of a range of pregnancy outcomes. |
|
Cost-effectiveness of antenatal testing for HIV. |
SCH. |
Graves N,
Ziegler JB. |
Analysis of
service delivery and laboratory costs of testing, health service
savings made and life years gained in various scenarios. |
| Chronic fatigue
in adolescents. |
SCH. |
Gill A,
Dosen
A,
Ziegler J. |
Study to
determine the long-term outcome of adolescent chronic fatigue
and assess the impact of early therapy. |
| Diagnosis of
peanut allergy in peanut sensitive children. |
Internal;
Sydney Children’s Hospital Foundation scholarship to B Wainstein. |
Wainstein B,
Ziegler J. |
This project
plans to assess the utility of a combination of clinical
history, skin prick testing, immediate patch testing and
measurement of circulating IgE antibody in the diagnosis of
peanut allergy. |
| Hepatitis in
mothers and infants study (HIMI). |
SCH. |
Palasanthiran
P, Elliot,
Ziegler J,
Best E, et al. |
Study of
hepatitis C virus (HCV) vertical transmission and HCV antibody
decline. |
Intensive Care
|
| Acute
respiratory distress syndrome in Australia. |
SCH. |
Numa A. |
This is a 12-month
observational study of Acute Respiratory Distress Syndrome in
children admitted to ICU in Australia and New Zealand, looking at
incidence, outcomes and causes. |
| Hypothermia in
traumatic brain injury in children (HITBIC). |
SCH. |
Numa A. |
This is a
multi-centre
study of the use of hypothermia as a treatment for severe head
injury. |
Medical Genetics
|
| An
investigation of the cognitive and behavioural phenotype of
Mowat-Wilson Syndrome. |
Sydney
Children’s Hospital Foundation. |
Mowat D,
Einfeld S,
Wilson M,
Evans E. |
A study of the
clinical features and cognitive and behavioural characteristics
(genetic and environmental) of
this newly recognised genetic syndrome. |
| A study of the
behavioural profile of Mowat-Wilson syndrome. |
UNSW Faculty
Research Grant. |
Einfeld S,
Mowat D,
Wilson M,
Evans D. |
A questionnaire
and direct assessment of the clinical features, level of
intellectual disability and behaviour in this syndrome. |
| Microarray
screening for DNA deletions causing intellectual disability. |
UNSW
Faculty Research Grant. |
Mowat D,
Einfeld S,
Turner G. |
Utilising
another method to identify submicroscopic chromosomal deletions
and/or duplications. |
| The Australian
Child to Adult Development Study. |
NH&MRC. |
Einfeld S,
Tonge B, Parmenter T, Turner G,
Mowat D. |
This is a longitudinal
study of behavioural and emotional problems in young people with
intellectual disability, investigating
the cause of intellectual disability in a community sample of
young people. |
| Implementation
of screening for Dystrophin point mutations in NSW families with
Duchenne Muscular Dystrophy. |
Muscular
Dystrophy Association of NSW. |
Buckley M,
Mowat D. |
Improving
mutation detection in Duchenne/Becker muscular dystrophy. |
| A clinical
approach to Duchenne/Becker Muscular Dystrophy. |
Muscular
Dystrophy Association of NSW. |
Buckley M,
Mowat D. |
Improving
mutation detection in Duchenne/Becker muscular dystrophy. |
| Outcome for
children with de novo balanced chromosomal translocations
detected on prenatal testing. |
Sydney
Children’s Hospital Foundation. |
Kirk E. |
This study aims
to discover the outcome for children born following the
diagnosis during prenatal testing of a particular type of chromosome
problem known as balanced reciprocal translocation. |
Multicultural Health Service
|
| Accounting for
culture within children’s health services in Sydney: a survey of
parents and carers. |
Westmead
Children’s Hospital; SCH. |
Chalmers S,
Choucair S,
White L, Lord B,
Eastwood J, Rosso-Buckton A,
Crawford J. |
Investigation
how parents and carers of ill children from culturally and
linguistically diverse (CALD) backgrounds fare during their
child’s hospitalisation. |
Nephrology
|
| HMG CoA
reductase inhibitors (statins) improve endothelial dysfunction
in children with chronic renal failure. |
Sydney
Children’s Hospital Foundation. |
Mackie F,
Rosenberg A, Kainer G, Miller O, Celermajer D. |
This trial
examines the effect of
statins (hormones produced by the hypothalamus
which stimulate the release of hormones in the pituitary gland) on
the function of cells lining blood and lymphatic vessels in children
with chronic renal failure. |
| Detection and
characterisation of smell and taste dysfunction in children with
chronic renal failure using psychophysical and anatomical
methods. |
Sydney
Children’s Hospital Foundation. |
Laing D,
Kainer
G. |
This project
will characterise smell and taste changes in patients with
chronic renal failure so that strategies can be developed for
managing their diet and nutrition. |
| Agreement on
reporting of ambulatory blood pressure monitoring in children. |
Sydney
Children’s Hospital Foundation. |
Kennedy S,
Mackie F, Rosenberg A, Craig E, Kainer G. |
A study of the
interpretation of ambulatory
blood pressure monitoring in
children by three paediatric nephrologists. |
| Urinary tract
infections in children: does 10 years make a difference? |
SCH. |
Doyle K,
Argent
E,
Kainer G. |
An audit to
determine whether the organisms that cause urinary tract
infection, and their antibiotic sensitivities, in children have
changed in the last 10 years. |
| Waiting time
and outcome of kidney transplantation in adolescence. |
SCH. |
Kennedy S,
Mackie F, Rosenberg A, McDonald S. |
To determine if
adolescent kidney transplant recipients have poorer graft
survival rates than children of other ages. |
Neurology & Neuroscience
|
| The
neuropsychological and language profile of children with benign
rolandic epilepsy. |
Australian
Brain Foundation; Financial Markets Foundation for Children. |
Bye A,
Connolly
A, Northcott E, McIntyre J, Christie J,
Lawson J,
Berroya A,
Bleasel A. |
A study to
evaluate the quality of life, cognitive and language profiles in
children with benign rolandic epilepsy. |
| The application
of statistical parametric mapping to the MRI of children with
epilepsy and malformations cortical dysplasia. |
Sydney
Children’s Hospital Foundation. |
Lawson J, Bye A. |
The technique
was evaluated for detection of brain tumours and brain
malformations in children with epilepsy. |
| Evaluation of a
problem-based learning and teaching approach in paediatric
neurology. |
Sydney
Children’s Hospital Foundation.
|
Bye A,
Looker P,
Netherton C, |
Evaluation of
the teaching about epilepsy through the use of video, by a clinician. |
| Immune-mediated
inflammation in dorsal root ganglia after peripheral nerve
injury and in sensory neuropathies. |
NH&MRC.
|
McLachlan E,
Cunningham A.
|
This project
explores basic mechanisms underlying the inflammatory response
to injury and disease in the nervous system, with relevance to
nerve injury and post-traumatic pain syndromes. |
| The biology of
olfactory neural stem cells and studies of cell lineage and
differentiation in the olfactory system using an in vitro
neurosphere model and time-lapse videomicroscopy. |
The Garnett
Passe and Rodney Williams Memorial Foundation; SCH. |
Cunningham A,
Kaplinovsky T, Marlicz W, Meedeniya A. |
A multifaceted
cell biological project aiming to identify and characterise the
unique neural stem cell present in the olfactory (smell) nervous system. |
| New therapies
for neurological injuries and diseases based on neural stem
cells. |
Australian
Brain Foundation. |
Cunningham A. |
This project
aims to further define the potential of adult nerve stem cells
for cell replacement therapies in nervous system disease and
traumatic injury. |
| Adult neural
stem cells and their potential therapeutic role in perinatal
cerebral injury. |
Lesley Stevens
Fund for Newborn Care. |
Ward M,
Cunningham A. |
This project
examines the responses of endogenous stem cells in the premature
and term brain, to various insults including lack of oxygen and
blood flow, mirroring the insults that can occur at the time of
birth. This has direct relevance to the underlying causes of
newborn brain damage and resultant conditions such as cerebral
palsy. |
| Expression of
the GDNF family of growth factors in the olfactory system. |
The Garnett
Passe & Rodney Williams Memorial Foundation; SCH. |
Maroldt H,
Kaplinovsky T, Cunningham A. |
The olfactory
(smell) system is unique in its support of robust nerve
generation and communication throughout adult
life. The regulation of these processes and the growth factors
involved are as yet poorly defined. This study involves
characterisation of the GDNF family of trophic factors in the
olfactory nervous system, aiming to define their mechanisms of
action on these unique stem cells and nerve cells. |
| Neurturin and
its receptor components in the olfactory system. |
Sydney
Children’s Hospital Foundation. |
Meedeniya A,
Maroldt H, Cunningham A. |
Neurturin is a
member of the GDNF family of growth factors thought to be
important in nervous system development and sensory systems.
This project explores the expression of the protein and its
receptor complex in the olfactory nervous system. |
| Differential
expression of two isoforms of the RET receptor tyrosine kinase
in the olfactory system, substantia nigra and other central
nervous system regions. |
The Garnett
Passe and Rodney Williams Memorial Foundation; SCH. |
Kaplinovsky T,
Cunningham A. |
GDNF is one of
the most potent growth factors in the human brain and has been used
in trials for Parkinson's disease, a condition of basal ganglia
degeneration. This project is defining the detailed localisation
of two distinctive isoforms of the GDNF receptor complex, which
are known to be capable of stimulating different downstream
signalling pathways, in brain regions relevant to Parkinson's
disease, memory and learning, and smell. |
| Proliferation,
differentiation and phenotypic outcome of endogenous neural stem
cells in an animal model of post-traumatic syringomyelia. |
Dalcross
Private Hospital; SCH. |
Liao J,
Stoodley M,
Tu J,
Cunningham A. |
A project using
an animal neurosurgical model of syringomyelia, a cystic
degenerative condition of spinal cord that occurs commonly after
spinal cord injury. These studies trace the response of stem
cells in the damaged spinal cord and determines the type of
nerve cells they become at various times post-injury. |
| Studies of the
up-regulation of expression of immature intermediate filament
proteins in the intestine of children with inflammatory bowel
disease. |
SCH. |
Leach S,
Day A,
Cunningham A. |
The diseased
bowel wall becomes inflamed and appears to up-regulate
immature cells, perhaps in an attempt to repair the process.
This project is studying the expression of various immature
markers in biopsies from patients with inflammatory bowel
disease, in an attempt to better understand these pathological
processes. |
| The usefulness
of the sleep disturbance scale for children (Bruni) as a
predictor of physiological problems during sleep in Duchenne
muscular dystrophy. |
SCH. |
Moline A,
Williamson B, Teng A, Betts G,
Pedersen R, Johnston H. |
A study to
determine if a questionnaire can detect breathing problems
during sleep in boys with Duchenne muscular to help to identify who needs specialised sleep monitoring. |
Neurosurgery
|
Vascular
targeting enhancement of radiosurgery
for arteriovenous
malformations. |
SCH. |
Stoodley M,
Storer K,
Smee R,
Tu J. |
Congenital
malformations of brain blood vessels are a leading cause of
stroke in children and young adults. Prevention of bleeding can
be achieved only by surgical removal or by obliteration with
high doses of radiation, which causes slow occlusion of vessels.
Some lesions are too risky to remove and too large to be treated
with radiation. The aim of this project is to enhance vascular
occlusion after radiation. |
Nursing Practice Development Unit
|
| An
investigation of multidisciplinary teamwork from the perspective
of clinicians working within patient care teams. |
Sydney
Children’s Hospital Foundation. |
Crisp J, Aston
J, Binns V, Wade C,
Dunlop S, Kepreotes H, Marshall L,
Moran P, White L,
Murdoch
J,
Prior A, Shi E, Tighe J, Wales S,
Visocnik F. |
First stage in
a series of studies aimed at building teamwork capacity within
the patient care teams. This study examined clinicians’
perceptions of their own and their team’s efficacy, effort and
skill levels. |
| Evaluation of a
child and family held care management folder. |
SCH. |
Hardy J, Crisp
J,
Macmillan C, Moran P,
O’Brien I. |
Evaluation of a
patient-held folder in improving continuity of care,
communication, satisfaction and confidence among children with
cancer, their families and health care providers. |
| Validation of
an instrument to measure adherence of adolescents with chronic
disease. |
SCH. |
Crisp J, Kyngas
H, Poole D, Nadew K, Thomsen A, Wales S. |
Reliability and
validity assessment of a tool measuring adherence levels in
adolescents with asthma or diabetes. |
Pain Medicine Unit
|
| School
functioning of children and adolescents with pain disorders: the
development and validation of the School Functioning Scale. |
Sydney
Children’s Hospital Foundation. |
Piira T, Betts
G, Chan E, McInerney M. |
This study aims
to develop the first reliable and valid school functioning
questionnaire for children with chronic pain. |
| Effect of
attentional coping strategies and individual difference factors
on children’s cold-pressor pain outcomes. |
School of
Psychology UNSW; SCH.
|
Piira T,
Hayes
B, Goodenough B. |
An experimental
study to learn more about the efficacy of children’s coping
strategies for pain and the role of individual difference
factors. |
| Parent verbal
behaviour and infant pain at immunisation: a randomised control
trial evaluating a
parent intervention. |
School of
Psychology UNSW, SCH. |
Bustos, T,
Piira, T, Salmon K |
Assessment of
whether coaching parents to use more coping promoting talk has a
positive effect on infant distress and pain responses following
an immunisation injection |
| Don’t break my
heart: Descriptors of social and physical pain across
ethnolinguistic groups |
Dalhousie
University, Halifax, Canada;
UCLA, Los Angeles, USA; SCH. |
Piira T,
Grégoire M-C, Clemente I.
|
A survey to
review the social and physical pain descriptors across a wide
range of languages. |
Respiratory
|
| S100 proteins
as markers of lung inflammation in young children with cystic
fibrosis. |
Rebecca Cooper
Foundation.
|
Belessis Y,
Day
A, Leach S,
Morton J. |
Assessment of
novel markers of airway inflammation in children with cystic
fibrosis. |
| Urinary
desmosine as a marker of lung inflammation in young children
with cystic fibrosis. |
SCH. |
Belessis Y,
Winfield K, Lui K,
Morton J, Numa A. |
Evaluating
urinary markers of elastin breakdown as indicators of lung
inflammation in young children with cystic fibrosis. |
| The lung
clearance index and its relationship to airway infection and
inflammation. |
SCH. |
Belessis Y,
Lui K,
Numa A, Morton J, O’Donovan B, Hawkins G, Xu L.
|
Assessing the
value of a new index of lung function in determining early
infection and inflammation in cystic fibrosis. |
School of Women's and Children's Health
|
An integrative model for improving medication safety in
children. |
Australian
Council for Safety and Quality in Health Care. |
Gazarian M,
Graudins L, the medication safety improvement project team. |
Study
evaluating an innovative strategy for reducing
medication errors and related harm in hospitalised children. |
| Safe
paracetamol use in children: development and evaluation of
caregiver medicine information. |
Australian
Council for Safety and Quality in Health Care. |
Sinha Y,
Graudins LV, Gazarian M. |
Development and
evaluation of a medicines information pamphlet for caregivers of
young children to improve the safe use of paracetamol.
|
| Studies of
smell and taste function and dysfunction in neonates. |
Leslie Stevens
Fund for Newborn Care; SCH. |
Laing D, Lui K,
Cunningham A, Hutchinson I, Bolton-Turner M. |
Developing
tests of smell and taste for infants to determine if they have
chemosensory disorders. |
| Clinical
aspects of chemosensory function. |
SCH;
Australian Postgraduate Award esearch scholarship to J Armstrong. |
Armstrong J,
Laing D.
|
This project
examines aspects of chemosensory function in children, a little
studied area. Studies are being undertaken of potential
abnormalities of the senses of smell and taste in disease
states, with a view to better managing paediatric patients with
these conditions. This includes evaluation of taste and smell in
Aboriginal children with chronic otitis media and nasal
infections. Another aspect is the development of a new test to
assess smell and taste function in young infants. |
| Once daily
gentamicin in infants and children: an evaluation of safety and
the role of therapeutic drug monitoring in minimising toxicity. |
Sydney
Children’s Hospital Foundation. |
Gazarian M,
Palasanthiran P, Best E, Cohn R,
Wilkinson M. |
Study
evaluating the safety of once daily administration of gentamicin
in children, especially with regard to hearing and renal
function, and the role of routine measurement
of drug levels in
minimising toxicity.
|
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