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Research

Clinical | Medical | Nursing | Pharmacy | Psychology | Research

The Albion Street Centre Research Unit has been actively involved in research since the Centre's inception in 1985. It has ongoing research interests in a number of areas relating to Human Immunodeficiency Virus (HIV), hepatitis C and sexual health.

The main areas of current research include clinical trials evaluating investigational new drugs as well as nutritional and behavioural aspects relating to both HIV and hepatitis C infections.

A number of international multicentre trials for investigational new drugs and collaborative studies with the National Centre in HIV Epidemiology and Clinical research have been, and will continue to be undertaken.

In-house studies are initiated by staff members from the Centre, and most of these are conducted in collaboration with other hospital sites and researchers. A number of these studies have been presented at major conferences and published in peer-reviewed journals.

The unit is actively involved in teaching and supervision of postgraduate students from the University of Sydney and the University of Wollongong.

Some staff members have secondary academic appointments with local universities and maintain ongoing research collaborations with these institutions.

 

Clinical trials recruiting at Albion Street Centre

  • HIV study for compassionate use of Maraviroc
  • HIV Darunavir once a day versus twice a day treatment study
  • Hepatitis C study (for HIV positive, hepatitis C co-infected patients)

 

Ongoing clinical trials

  • HIV ESPIRIT Interleukin-2 study
  • HIV SILCAAT interleukin-2 study
  • HIV gene therapy study
  • HIV Tipranavir treatment studies (3 different studies)
  • HIV STEAL study (treatment using Truvada or Kivexa)
  • HIV Raltegravir versus Kaletra study
  • HIV ARTEMIS study: Darunavir versus Kaletra treatment
  • HIV Avexa treatment study
  • HIV in semen study
  • HIV Maraviroc study for treatment naïve patients
  • HIV Maraviroc study for treatment experienced patients
  • Hepatitis C Chariot study (interferon treatment for HIV and hepatitis C co-infected patients)

Please feel free to phone the Albion Street Centre (02 9332 9600) and speak to the research department staff if you are interested in finding out more about existing or new studies.

 

Publications List 2008

1. S Lewin, J Murray, A Solomon et al (D Smith-author). Virologic determinants of success after structured treatment interruptions of antiretrovirals in acute HIV-1 infection. JAIDS 2008; 47(2):140-147.

2. Chan D, McNally L, Batterham M, Smith DE. Relationship between HIV-RNA load in blood and semen in antiretroviral-naive and experienced men and effect of asymptomatic sexually transmissible infections. Curr HIV Res 2008; 6:138-142.

3. Jeganathan S, Bansal M, Smith DE , Gold J. Comparison of different methodologies for CD4 estimation in a clinical setting. HIV Med 2008; 9:192-195.

4. Gold J and Tomkins M (contributing authors). Post-exposure prophylaxis to prevent HIV infection. Joint WHO/ILO guidelines on post-exposure prophylaxis (PEP) to prevent HIV infection.

5. Chan D, McNally L. Assays for the determination of HIV-1 load in semen: a review of indications, methods and performance in vitro. Curr HIV Res 2008; 6:182-188.

6. Begley K, McLaws ML, Ross MW, Gold J. Cognitive and behavioural correlates of non-adherence to HIV antiretroviral therapy: theoretical and practical insight for clinical psychology and health psychology. Clin Psych. 2008; 12(1):9-17.

7. Ramanathan V, Kang M, Jeganathan S, Jackson E, Lagios K, Furner V. Accessibility and acceptability of public sexual health clinics for adult clients in New South Wales, Australia. Sexual Health. 2008; 5:305-306.

8. Chan D. Penicillin treatment for early syphilis in the presence of HIV-1 infection: the long or the short of it. Int J STD and AIDS. 2008; 19:648.

9. Voirin N, Routy J, Smith D et al. Effect of early initiation of highly active antiretroviral therapy on CD4 cell count and HIV-RNA viral load trends within 24 months of the onset of acute retroviral syndrome. HIV Med 2008; 9:440-444.

10. Smith D. New antiretroviral agents and the complexity of treatment practises. J HIV Therapy.2008;13(2):25.

11. Chan DJ, Ray JE, McNally L, Batterham M, Smith DE. Correlation between HIV-1 RNA load in blood and seminal plasma depending on antiretroviral treatment status, regimen and penetration of semen by antiretroviral drugs. Curr HIV Res 2008; 6: 477-484.

12. Begley K, Chan DJ, Jeganathan S, Batterham M, Smith DE. Correlates of unprotected anal intercourse in HIV positive men attending an HIV/AIDS clinic in Sydney. Curr HIV Res 2008; 6: 579-584.

13. Emerson C, Post JJ. To routinely offer HIV testing in all cases of tuberculosis: a rational clinical approach? Med J Australia. 2008; 188(3):162-3.

 

Publications with ASC acknowledged-Multicentre Studies

1. Carr A, Grund B, Newhaus J et al (ASC member of study group) Asymptomatic myocardial ischaemia in HIV-1 infected adults. AIDS 2008, 22: 257-267.

2. The Strategies for Management of Antiretroviral Therapy (SMART) Study Group. Inferior clinical outcome of the CD4+ cell count guided antiretroviral treatment interruption strategy in the SMART study: role of CD4+ cell count and HIV RNA levels during follow-up. JID 2008; 197:1145-1155.

3. Determination of the underlying cause of death in three multicenter international HIV clinical trials. A Lifson and INSIGHT Cause of Death Writing Group. HIV Clinical Trials 2008; 9(3):177-185.

4. Bodsworth N, Bloch m, McNulty A et al (ASC was a member of the study group). 2-day versus 5-day famciclovir as treatment of reoccurrences of genital herpes: results of the FaST Study. Sexual Health 2008; 5:219-225.

5. The SMART and D:A:D Study Groups (ASC-member of SMART). Use of nucleoside reverse transcriptase inhibitors and risk of myocardial infarction in HIV-infected patients. HIV Med 2008; 9: 440-444

 

Conference Presentations

1. Emerson CR, Goldberg H, Vollmer-Conna U, Post JJ. Self reported human immunodeficiency virus infection testing practice among physicians treating tuberculosis in Australia and New Zealand. British HIV Association Annual Conference, Glasgow, April 2008.

2. Chan DJ, Ray JE. Differential penetration of antiretroviral agents in aemen and effect on seminal plasma HIV-1 RNA load. XVII International AIDS Conference, Mexico City, 2008.

3. Chan DJ, Begley K. A model for HIV-1 transmission amongst men who have sex with men according to sexual behaviour, optimism-scepticism, and sexual beliefs about plasma HIV-1 load and infectivity. XVII International AIDS Conference, Mexico City, 2008.

4. Post JJ. Testing for latent tuberculosis in HIV patients-the old or the new? (Invited Speaker). 20th ASHM Perth, 20th September 2008.

5. Furner VL, Moreton R, Tawil V, Christensen A. The TB + HIV connection. 20th ASHM Perth, 20th September 2008.

6. Hill R, Ryan B, Sadler S, Sarangapany J, Begley K, Wyndham H, Cousins J, Nicol K, Kalinoe M, Miria R. Potential difficulties and barriers: findings from a knowledge, attitudes and practice survey in Papua New Guinea. 20th ASHM Perth, 20th September 2008.

7. Di Guilmi A, Sarangapany J, Houtzager L, Young J, Purnomo J, Begley K. Validating a two-question depression screening tool in an HIV-positive population to use in improving nutrition outcomes and prognosis. 20th ASHM Perth, 20th September 2008.

8. Di Guilmi A , Sarangapany J, Houtzager L , Young J , Purnomo J , Begley K. Validating an abridged symptoms distress questionnaire in an HIV-positive population to facilitate dietetic referral and improve nutrition outcomes. 20th ASHM Perth, 20th September 2008.

9. Purnomo J, Young J, Sarangapany J, Houtzager L, Di Guilmi A. Reduced energy and increased saturated fat intake in a cohort of HIV positive clients in Sydney. 20th ASHM Perth, 20th September 2008.

10. Di Guilmi A, Sarangapany J, Houtzager L , Young J, Purnomo J, Begley K. Development and reliability testing of nutrition screening criteria for use in HIV-1 infected patients. 20th ASHM Perth, 20th September 2008.

11. Ramanathan V, Sarangapany J, Kang M . Demographic characteristics of clients accessing public sexual health clinics in New South Wales. 20th ASHM Perth, 20th September 2008.

12. Green A, Hennessy R. Understanding domestic violence and same sex domestic violence in a HIV ambulatory care setting. 20th ASHM Perth, 20th September 2008.

13. Tomkins M, Gold J. Implementation issues arising from the 2008 WHO/ILO post exposure prophylaxis guidelines. 20th ASHM Perth, 20th September 2008.

14. Cherry R, Melling P, Wyndham H. Sharp practice: thirteen years of the NSW needlestick injury hotline. 20th ASHM Perth, 20th September 2008.

15. Millar K, Price A. A review of patients who have presented late with advanced HIV disease. 20th ASHM Perth, 20th September 2008.

16. Smith ML. Cervical screening (pap smears) attendance in HIV positive women: a nursing audit. 20th ASHM Perth, 20th September 2008.

17. Young J, Sarangapany J, Houtzager L , Di Guilmi A, Purnomo. Validation of an abridged food security tool and evaluation of oral health risk in a HIV-1 infected cohort. 20th ASHM Perth, 20th September 2008.

 

Albion Street Centre
150 - 154 Albion Street Surry Hills NSW 2010 Australia
Telephone: +61 2 9332 9600 Fax: +61 2 9331 3490